QuickBooks Transport Layer Security (TLS) errors can arise due to outdated TLS settings or compatibility issues with the operating system. These errors hinder users from accessing company files and conducting essential financial tasks. Troubleshooting involves verifying TLS settings, adjusting Internet Explorer configurations, and ensuring firewall and security software compatibility. Updating QuickBooks and the operating system, along with educating users on TLS requirements, are crucial preventive measures. Resolving TLS errors ensures secure connections and uninterrupted access to QuickBooks, promoting efficient business operations.