Cancer-Associated Fibroblasts (CAFs)

Cancer-associated fibroblasts, or CAFs, are a type of stromal cell commonly found in the tumor microenvironment. They are associated with all stages of cancer and contribute to its progression in various ways. CAFs can increase the rate of cancer cell growth, promote the formation of new blood vessels, and facilitate the spread of cancer cells to other parts of the body.

In addition to these effects, CAFs can also suppress the immune system's ability to fight cancer by recruiting immunosuppressive cells and inhibiting the activity of cytotoxic T lymphocytes. This can lead to the development of drug resistance and cancer recurrence. CAFs also play a role in promoting cancer stemness, which can contribute to the resistance of cancer cells to treatment. As such, targeting CAFs has emerged as a promising therapeutic strategy for cancer therapy.

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